Intraepithelial carcinoma (Bowen disease) - 上皮内癌
典型的なケース ― 上皮内癌 (Intraepithelial carcinoma (Bowen disease)) は、長期にわたるかゆみのない湿疹として誤診される可能性があります。
relevance score : -100.0%
ReferencesBowen's disease (BD) は、皮膚の外層（表皮）にできる皮膚がんの一種です。白人に多く見られ、日光が当たる部位で特に発生しやすいですが、日光に当たらない部位でも起こり得ます。BD は通常、単一の病変として現れ、より重篤な皮膚がんが発症する前の警告サインとみなされることがあります。診断の際は、医師が顕微鏡下で組織サンプル（生検）を検査します。
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease は、主に60歳以上の白人に罹患します。主な危険因子として、長期にわたる日光曝露、免疫システムの低下、ヒ素曝露、皮膚HPV感染などが挙げられます。HPV株16、18、34、48は、生殖器領域のBowen's diseaseに関連しています。非生殖器症例におけるHPVの関与はあまり明らかではありません。
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
通常、紅斑・鱗屑・かさぶた状の病変として体のどこかに現れ、最も多い部位は下肢です。
凍結療法、掻爬術、焼灼、光線力学療法、病変の切除など、さまざまな治療オプションで治癒が期待できます。
○ 診断と治療
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy